Investigating the Efficacy of Web-Based Transfer Training on Independent Wheelchair Transfers Through Randomized Controlled Trials

Objectives

To determine the efficacy of a web-based transfer training module at improving transfer technique across 3 groups: web-based training, in-person training (current standard of practice), and a waitlist control group (WLCG); and secondarily, to determine subject factors that can be used to predict improvements in transfer ability after training.

Gait Training in Acute Spinal Cord Injury Rehabilitation—Utilization and Outcomes Among Nonambulatory Individuals: Findings From the SCIRehab Project

Objectives

To investigate the relation of gait training (GT) during inpatient rehabilitation (IPR) to outcomes of people with traumatic spinal cord injury (SCI).

Impact of Regular Physical Activity on Adipocytokines and Cardiovascular Characteristics in Spinal Cord–Injured Subjects

Objective

To investigate the relationship of carotid artery intima-media thickness (IMT) and cardiac structure and function with adipocytokines in sedentary (S-SCI) and physically active (PA-SCI) subjects with spinal cord injury (SCI).

一氧化碳中毒迟发性脑病与脑细胞自噬的研究进展

一氧化碳中毒迟发性脑病(delayed encephalopathy after carbon monoxide poisoning,DEACMP)的发病率较高,对患者及家庭造成极大的痛苦和经济负担,其发病机制仍然不明。一氧化碳中毒时,一氧化碳可通过多种途径启动脑细胞自噬。自噬参与了DEACMP的发病,但自噬在疾病不同阶段的水平及发挥的作用,仍未得出一致的结论。     

老年脊髓损伤患者生存质量影响因素分析

目的:研究老年脊髓损伤(SCI)患者生存质量的相关影响因素,从而提出改善其生存质量的措施,提高老年SCI患者的生存质量。方法:选取60岁以上SCI患者100名,根据国内外文献及我国社会文化背景,选出可能影响老年SCI患者生存质量的因素15项,自行设计问卷进行调查,同时采用世界卫生组织生存质量测定量表简表(WHOQOL-BRIEF)进行生存质量评分。结果:经分析,15项因素中影响老年SCI患者生存质量的变量为8个,分别是年龄、神经损伤平面、损伤性质、生活自理能力、并发症及慢性病数、社会支持、医疗费用方式、居住方式,复相关系数为0.779。其中年龄、并发症及慢性病数与生存质量呈负相关(P0.01),生活自理能力、社会支持与生存质量呈正相关(P0.01)。损伤神经平面自上向下生存质量由低至高,脊髓不完全损伤的生存质量高于完全损伤的生存质量(P0.01),医疗费用有保障的老年SCI患者生存质量更高(P0.05),集中居住的老年SCI患者比分散居住的生存质量略高(P0.05)。结论:年龄、损伤神经平面、损伤性质、生活自理能力、并发症及慢性病数、社会支持、医疗费用方式、居住方式都是影响老年SCI患者的生存质量的主要因素。     

18F-FDG PET/CT利尿延迟显像膀胱放射性廓清效果的影响因素

目的 探讨¹⁸F-FDG PET/CT利尿延迟显像膀胱放射性廓清效果的影响因素。方法 回顾性收集85例盆腔利尿延迟显像患者的PET/CT资料,测量膀胱常规及利尿延迟显像最大标准化摄取值（SUV_max）,记录延迟时间;分析常规显像膀胱SUV_max、呋塞米注射途径（静脉注射或肌内注射）、延迟时间、年龄、性别因素对利尿延迟显像膀胱SUV_max的影响。结果 根据呋塞米注射途径不同,分为静脉注射组（n=34）和肌内注射组（n=51）,2组利尿延迟显像膀胱SUV_max分别为3.10（2.60,3.45）和2.90（2.30,3.90）,差异无统计学意义（Z=-0.894,P=0.372）;延迟显像时间分别为¹⁸F-FDG注射后（215.00±30.03）min和（198.43±25.19）min,差异有统计学意义（t=-2.655,P=0.010）。2组间年龄差异无统计学意义（t=1.150,P=0.253）,2组中不同性别患者间延迟显像膀胱SUV_max差异均无统计学意义（P均>0.05）。静脉注射组和肌内注射组利尿延迟显像膀胱SUV_max与延迟时间和患者年龄均无明显相关性。结论 注射¹⁸F-FDG后充分水化、应用呋塞米利尿,约180 min行盆腔延迟显像能显著降低膀胱放射性,患者年龄、性别、呋塞米注射途径对于膀胱放射性廓清效果无明显影响。     

DTI定量评价大鼠急性创伤性脊髓损伤后功能改变

目的 探讨DTI定量参数动态评价大鼠不同程度急性创伤性脊髓损伤（TSCI）后功能改变的价值。方法 采用改良Allen打击法制备轻度、中度及重度损伤组大鼠急性TSCI模型各10只。于损伤前、损伤后即刻、6 h、24 h、3天、7天及14天分别行DTI检查及运动功能评分（BBB）评分,获得并比较轻、中、重度损伤组大鼠TSCI后不同时间点DTI参数值及BBB评分的差异,分析大鼠BBB评分与各参数间的相关性。结果 轻、中、重度损伤组间和TSCI后不同时间点间FA、MD及RD值差异均有统计学意义（P均<0.05）;TSCI后不同时间点间AD值差异有统计学意义（F=12.720,P<0.001）,而轻、中、重度损伤组间AD值差异无统计学意义（F=0.469,P=0.630）。大鼠TSCI后即刻FA、MD值减低,RD值升高,后FA值持续降低,MD和RD值持续升高至24 h （P均<0.05）,24 h后趋于稳定（P均>0.05）。大鼠BBB评分损伤后即刻降至最低值,之后持续上升（P均<0.05）,且BBB评分与MD相关性最高（r=0.958,P<0.01）。结论 DTI可动态定量评价大鼠TSCI后功能改变;推测TSCI后1天之内可能为治疗最佳时间窗。     

Beta-adrenergic stimulation of pig myocytes with decreased cytosolic free magnesium prolongs the action potential and enhances triggered activity

INTRODUCTION: Heart failure results in chronic beta-adrenergic stimulation, repolarization lability, and arrhythmias associated with early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs). Having described a significant reduction in intracellular free magnesium ([Mg2+]i) in experimental heart failure, we asked whether a reduction in [Mg2+]i would delay repolarization or facilitate EADs and/or DADs. METHODS AND RESULTS: Left ventricular myocytes were isolated from Yorkshire swine. Cytosolic free [Mg2+] was set at 0.12 mM (LoMg) or 1.2 mM (HiMg) through pipette dialysis. Action potentials (AP), Ca current (I(Ca)), and sodium/calcium exchange current (I(NCX)) were measured in the presence or absence of isoproterenol (2 microM) at 37 degrees C. Under basal conditions (0.1-Hz stimulation, 2 mM external [Ca2+]), reducing [Mg2+]i had no effect on AP duration and I(Ca) but did significantly enhance I(NCX). In contrast, during superfusion with isoproterenol, reduced [Mg2+]i caused a significant increase in AP duration at both 50% and 90% repolarization (APD50 and APD90) compared with HiMg (P < 0.05). LoMg cells manifested a high incidence of triggered activities, including spontaneous AP, EADs, and DADs (83.3% in LoMg, n = 12 vs 38.3% in HiMg, n = 13; P < 0.05). I(Ca) and I(NCX) were significantly increased in LoMg cells compared with HiMg cells (P < 0.05). CONCLUSION: Decreased cytosolic free magnesium prolongs AP duration and increases the incidence of triggered activity during beta-adrenergic stimulation. These effects may be due to increased I(Ca) and I(NCX) in the presence of reduced intracellular [Mg2+]. A magnesium-dependent increase in triggered activity coupled with delayed repolarization during beta-adrenergic stimulation could contribute to the arrhythmogenic substrate in heart failure.